The digestive tract is home to many microbial populations. The intestine is a warm, moist niche where the appropriate food for the intestinal bacteria can flourish for the good intestinal bacteria. But the use of antibiotics destroys this symbiosis and causes abnormal changes in the intestinal flora, which the emergence eg may favor infection, atopy, inflammatory bowel diseases, diabetes and arthritis. In our modern society the widespread administration of antibiotics is one of the main causes of changes in the bacterial flora of the intestine.
Our holistic health benefits depends from a balanced intestinal bacterial flora:
They support our resistance to infection
It ensures the optimal absorption of nutrients in the intestine.
Equally important is the influence of intestinal flora on the mucosal immune system . The mucosal immune system contributes to the development and differentiation of the immune system and prevents abnormal changes in the intestinal flora, which ( infections, atopy, inflammatory bowel disease, diabetes and arthritis) might cause the above mentioned health problems.
Antibiotics disrupt the intestinal flora and thus the immune defense against pathogens.
Moreover, as recent studies have shown additional effects of antibiotics on the intestinal flora such as stimulation of gene transfer between gut bacteria and reduction of immune responses in peripheral organs.
For example, can affect ciprofloxacin the bacterial balance in the gut, resulting in a reduction in the diversity and a healthy and uniform distribution of bacteria the .
It has been shown in numerous publications that the reduce the microbial diversity of the intestinal bacteria increases susceptibility to intestinal infections.
This existence of a so-called dysbiotic status leads to a changes in homeostasis and activation of inflammasomes. Inflammasomes are protein scaffolds, which play a significant role in the origin of inflammation in the mucous membranes and other tissues.
What to do about it?
Prevention is the preferred way to limit an adverse development through the use of antibiotic therapy. The use of probiotics has shown that they are capable of in front of you while after antibiotic therapy to gain and health benefits. Bifidobacteria and prebiotics, and the use of butyrate also represent practical procedures to bring an altered immune system and the intestinal bacterial flora into balance.
Research into the potential use of probiotic lactic acid bacteria to improve the aspects of the immune system to antagonize pathogens and counteract dysbiosis, has shown that it is important to make recommendations for the clinical use of probiotics to prevent with the aim of diseases and to achieve an improvement of the immune system.